Science shows that sleep is important for cognition, cardiovascular health, and balanced mood, but many of us aren’t getting the restful sleep we need. R.E.M. Maintenance is non-habit forming and provides nutrients that support both physical and mental relaxation. Melatonin and 5-HTP are included in the formula to help bring on sleep, magnesium and potassium aid in muscle relaxation, and both glycine and inositol ease nervous tension.
R.E.M. Maintenance powder is a unique blend of nutraceuticals formulated to support normal, healthy sleep.
- Glycine is an inhibitory neurotransmitter that improves sleep quality due to its role in suppression of muscle twitches in REM sleep and decreasing body core temperature.*
- Magnesium and potassium are minerals shown to improve sleep quality and aid in muscle relaxation. Magnesium has been linked to regulation of biorhythms.*
- Inositol supports neurotransmitter receptor function, and may ease nervous tension.*
- 5-HTP is a direct precursor to serotonin, a neurotransmitter involved in sleep/wake cycles.*
- Melatonin is a hormone produced by the pineal gland that regulates circadian rhythms. Low-dose melatonin has been shown to enhance sleep onset.*
Precautions: R.E.M. Maintenance™ contains 5-HTP which should not be taken with MAO inhibitors or tricyclic antidepressants. May cause drowsiness. Do not drive or operate heavy machinery after taking this product. Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
References:
Erland, Lauren AE, and Praveen K. Saxena. “Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content.” Journal of Clinical Sleep Medicine 13.02 (2017): 275-281.
Hardeland, Rüdiger. “Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction.” The Scientific World Journal 2012 (2012).
Cauffield, Jacintha S., and Hiroko Jm Forbes. “Dietary supplements used in the treatment of depression, anxiety, and sleep disorders.” Lippincott’s primary care practice 3.3 (1999): 290-304.
Mukai, Tomohiko, et al. “A meta‐analysis of inositol for depression and anxiety disorders.” Human Psychopharmacology: Clinical and Experimental 29.1 (2014): 55-63.
Kawai, Nobuhiro, et al. “The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.” Neuropsychopharmacology 40.6 (2015): 1405.
Breus, Micheal. “Understanding Glycine”. The Sleep Doctor. July 23, 2018. https://thesleepdoctor.com/2018/07/23/understanding-glycine/
Popoviciu, L., et al. “Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency.” Revue Roumaine de Neurologie et Psychiatrie (1993).
Wienecke, E., and C. Nolden. “Long-term HRV analysis shows stress reduction by magnesium intake.” MMW Fortschritte der Medizin 158.Suppl 6 (2016): 12-16.
Durlach, J., et al. “Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion.” Magnesium research 15.1-2 (2002): 49-66.
Poleszak, Ewa. “Benzodiazepine/GABAA receptors are involved in magnesium-induced anxiolytic-like behavior in mice.” Pharmacological Reports 60.4 (2008): 483.
National Institutes of Health. Magnesium Fact Sheet for Professionals. Accessed Dec 10, 2018. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/.
Cornelius, Jason R., et al. “Sleep manifestations of voltage-gated potassium channel complex autoimmunity.” Archives of neurology 68.6 (2011): 733-738.
Sack, Robert L., et al. “Human melatonin production decreases with age.” Journal of pineal research 3.4 (1986): 379-388.
* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
